Shimadzu releases ultra-fast preparative and purification liquid chromatograph

14 June 2016 | News | By NFS Correspondent

Shimadzu has released the ‘Prominence UFPLC’ Ultra-Fast Preparative and Purification Liquid Chromatograph,  which enables  fast recovery of highly purified target compounds from complex  samples  such  as organic   synthesis   reaction   mixtures and  natural  products.
Conventional workflows that utilise preparative liquid chromatography (Prep LC) yield fractions with significant water content, which can take eight hours or  more  to  evaporate and  typically cannot  be  completely  removed, resulting in a powder with poor weight  purity.
The Prominence  UF- PLC is a single automated workflow that utilises on-line fraction trapping as an alternative  to traditional  fraction collection, allowing elution of collected  compounds in highly volatile organic  solvents  that  can easily be evaporated, resulting  in ultra-high  weight  purity  compounds in about  90 minutes. The Prominence UFPLC greatly improves the efficiency of preparative  fraction collection and  purification  workflows in pharmaceutical, food, chemical and other industries  as well as research  organisations.
Prep LC is a widely used  technique in   many    research,    development and manufacturing applications, including  the  synthesis  of new  drug compounds, the discovery of active components  in   natural   products, and as a mechanism  to collect large amounts  of  unknown   compounds in foods  and  drugs  for subsequent structural analysis.
In 2013, Shimadzu released  the  ‘Crude2Pure’ Auto- mated Purification/Powderisation System, which accepted PrepLC fractions, removed mobile phase contaminants, and returned a highly pure  and  very dry powder, with an option  to recover that  powder  as a free base. Prominence UFPLC inherits the breakthrough fraction trapping and purification technology at the core of Crude2Pure and expands on it to provide a comprehensive on- line automated purification process.
The Prominence UFPLC seamlessly integrates traditional Prep LC with novel fraction trapping for up to five compounds of interest. The instrument  is controlled  by  a  dedicated walk-up software designed to empower non-expert users to easily set conditions for chromatographic separation and isolation of target  com- pounds, trapping, purifying, eluting and  collecting  highly purified com- pounds  in as little as 90 minutes. For applications  involving the  isolation of low concentration targets, replicate  injection  and  collection to the same  trapping   column  to  increase the  amount  of compound trapped on column  prior to elution  is easily accomplished.
With the introduction of Prominence UFPLC, Shimadzu expands its extensive chromatography portfolio to include a  comprehensive automated solution for preparative  separations, fraction purification and compound powderisation,  contributing greatly to improved  efficiency in any application that  requires preparative  purification.Shimadzu releases ultra-fast preparative and purification liquid chromatograph.
Shimadzu has released the ‘Prominence UFPLC’ Ultra-Fast Preparative and Purification Liquid Chromatograph,  which enables  fast recovery of highly purified target compounds from complex  samples  such  as organic   synthesis   reaction   mixtures and  natural  products.
Conventional workflows that utilise preparative liquid chromatography (Prep LC) yield fractions with significant water content, which can take eight hours or  more  to  evaporate and  typically cannot  be  completely  removed, resulting in a powder with poor weight  purity.
The Prominence  UF- PLC is a single automated workflow that utilises on-line fraction trapping as an alternative  to traditional  fraction collection, allowing elution of collected  compounds in highly volatile organic  solvents  that  can easily be evaporated, resulting  in ultra-high  weight  purity  compounds in about  90 minutes. The Prominence UFPLC greatly improves the efficiency of preparative  fraction collection and  purification  workflows in pharmaceutical, food, chemical and other industries  as well as research  organisations.
Prep LC is a widely used  technique in   many    research,    development and manufacturing applications, including  the  synthesis  of new  drug compounds, the discovery of active components  in   natural   products, and as a mechanism  to collect large amounts  of  unknown   compounds in foods  and  drugs  for subsequent structural analysis.
In 2013, Shimad- zu released  the  ‘Crude2Pure’ Auto- mated Purification/Powderisation System, which accepted PrepLC fractions, removed mobile phase contaminants, and returned a highly pure  and  very dry powder, with an option  to recover that  powder  as a free base. Prominence UFPLC inherits the breakthrough fraction trapping and purification technology at the core of Crude2Pure and expands on it to provide a comprehensive on- line automated purification process.
The Prominence UFPLC seamlessly integrates traditional Prep LC with novel fraction trapping for up to five compounds of interest. The instrument  is controlled  by  a  dedicated walk-up software designed to empower non-expert users to easily set conditions for chromatographic separation and isolation of target  com- pounds, trapping, purifying, eluting and  collecting  highly purified com- pounds  in as little as 90 minutes. For applications  involving the  isolation of low concentration targets, replicate  injection  and  collection to the same  trapping   column  to  increase the  amount  of compound trapped on column  prior to elution  is easily accomplished.
With the introduction of Prominence UFPLC, Shimadzu expands its extensive chromatography portfolio to include a  comprehensive automated solution for preparative  separations, fraction purification and compound powderisation,  contributing greatly to improved  efficiency in any application that  requires preparative  purification.

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