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Diabetes and antioxidants

27 MAR,2017 | Mumbai

Dr Sanjay Agrawal Leading pharmaceutical consultant and Editor-in Chief of IJMToday
antioxidant defences

Diabetes is a chronic metabolic disorder with a rapidly increasing prevalence highlighting the importance of continued research and need for novel methods to both prevent and treat this pandemic. Although obesity and physical inactivity are known to be major risk factors for type 2 diabetes (T2DM), recent evidence suggests that oxidative stress may contribute to the pathogenesis of T2DM by increasing insulin resistance or impairing insulin secretion.

While diabetes management has largely focused on control of hyperglycaemia, the rising burden of this disease is mainly correlated to its vascular complications. This is reflected by a four-fold increase in the incidence of coronary artery disease, a ten-fold increase in peripheral vascular disease, and a three to four-fold higher mortality rate with as much as 75 per cent of diabetics ultimately dying from vascular disease.

Oxidative stress may play a role in the pathophysiology of diabetes and cardiovascular disease. Consequently, the question of whether antioxidants could have a beneficial effect on reducing the risk of these conditions, especially cardiovascular disease, has been intensively investigated, but the results remain inconclusive. If antioxidants play a protective role in the pathophysiology of diabetes and cardiovascular disease, understanding the physiological status of antioxidant concentrations among people at high risk for developing these conditions, such as people with metabolic syndrome, is of interest.

What does mold have to do with diabetes?

Nothing. Mold has nothing to do with the direct cause of diabetes. It does, however, provide an early warning sign to diabetics who aren’t properly monitoring their blood-sugar levels and those who aren’t even aware that they have diabetes.

Mold, an opportunistic fungus that generally wreaks havoc on the human body, is finally — in a rare act of consequential benevolence —proving to be useful. The mere fact that mold thrives on organic material, especially organic material that consists of sugar, is precisely why it is important to observe its presence and whereabouts — not just to remove and prevent it but to gain a glimpse of our own state of health.

Many mold victims complain of mold growing in their clothing and in their toilet bowl. This mold can appear fuzzy, slimy, and grey, black, or brown in colour. While this can easily occur from infrequent washing and sanitation of either the person, the clothing, or the toilet bowl, and is also a sign of an overall mold infestation throughout the home, it is a major indication of blood-sugar levels in the sweat and urine of the individual.

If the body is overwhelmed by glucose, it will attempt to flush as much of the excess out of its system by means of sweat, exhalation, and urination. It is quite plausible that the mold found in your clothing or in your toilet bowl is a sign that your body is truly suffering from an abundance of glucose and needs help. It’s a commonly overlooked correlation, but it has the potential to save your life.

Diabetes & oxidative stress

A number of complications arise as a consequence of macro and microvascular complications that result from diabetes; these deficits have a central role in the tissue-damaging effects of chronic hyperglycaemia. Since endothelial cells (as well as renal mesangial and Schwann cells) are unable to limit glucose transport as well as other cells do, they are more vulnerable to the toxic effects of hyperglycaemia.

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